An inherited 1;G translocation.

A child with multiple congenital anomalies and retardation was found to have a translocation involving chromosome No. 1 and a chromosome of the G group. The affected child has a minute centric fragment of unknown origin in addition to the 1;G translocation. Although the translocation is found throughout 4 generations, the child described here is the only known instance of fetal abnormality in this family. To our knowledge there are only three other reports of a translocation between chromosome No. 1 and a G chromosome (Kontras et al, 1966; Maganias et al, 1967; Wilson, 1969). In two of these families the translocation was transmitted from mother to child. In this family the translocation is transmitted from both male